Dimethenamid-p/racemic Dimethenamid
نویسندگان
چکیده
Explanation.................................................................................................. 189 Evaluation for acceptable daily intake......................................................... 190 Biochemical aspects ......................................................................... 190 Absorption, distribution and excretion ....................................... 190 Metabolism ................................................................................. 194 Toxicological studies ....................................................................... 202 Acute toxicity ............................................................................. 202 Short-term studies of toxicity ..................................................... 206 Long-term studies of toxicity and carcinogenicity ..................... 213 Genotoxicity ............................................................................... 217 Reproductive toxicity ................................................................. 218 Multigeneration studies......................................................... 218 Developmental toxicity ......................................................... 220 Special studies ............................................................................ 225 Neurotoxic potential.............................................................. 225 Induction of liver enzymes.................................................... 225 Haemoglobin binding potential............................................. 227 Studies on metabolites .......................................................... 227 Observations in humans ................................................................... 229 Comments.................................................................................................... 230 Toxicological evaluation ............................................................................. 232 References ................................................................................................... 235
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